Matched Analysis of Circulating and Adipose Tissue SIRT1 Protein Level in Human Obesity
: In this pilot study, our results show that the plasma SIRT1 levels substantially reflect those of SAT in patients with obesity. Given the metabolic role of SIRT1, further comprehensive investigations in larger longitudinal cohorts are needed to support plasma SIRT1 as an eligible diagnostic tool for stratifying metabolic risk associated with fat mass expansion in obesity.
Authors
- Luisa Salvatori (ORCID: https://orcid.org/0000-0003-2286-9869)
- Carla Lubrano (ORCID: https://orcid.org/0000-0001-8261-1451)
- Daniele Gianfrilli (ORCID: https://orcid.org/0000-0002-2682-8266)
- Francesca Megiorni (ORCID: https://orcid.org/0000-0003-3705-3248)
- Lucio Gnessi (ORCID: https://orcid.org/0000-0001-8217-2372)
- Orietta Gandini (ORCID: https://orcid.org/0000-0002-7867-1010)
- Elena Gangitano (ORCID: https://orcid.org/0000-0003-1044-2278)
- Stefania Mariani (ORCID: https://orcid.org/0000-0003-1762-4701)
- Eleonora Poggiogalle (ORCID: https://orcid.org/0000-0003-0862-5892)
- Mikiko Watanabe (ORCID: https://orcid.org/0000-0003-2225-8814)
- Valentina Ventimiglia
- Antonio Angeloni
- Andrea Maria Isidori
- Giorgia Maria Baldazzi
Institutions
- Institute of Molecular Biology and Pathology (IT)
- National Research Council (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Nutrients
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/nu18081239
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00