Upregulation of Caveolin-1 in breast cancer and its potential value in distinguishing TNBC from non-TNBC: an immunohistochemical study

< 0.001). We further analyzed the value of CAV-1 in distinguishing between TNBC and non-TNBC, the results showed that the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CAV-1 positive prediction for TNBC were 32.9%, 98.6%, 90.0%, and 79.5%, respectively. Regardless of all breast cancer or TNBC patients, no clear relationship was observed between patient prognosis and CAV-1 expression. We suggest that CAV-1 expression is significantly upregulated in TNBC, with potential clinical value for distinguishing between TNBC and non-TNBC.