OTUB2 induces M2 tumor-associated macrophage polarization and increases CD274 expression in gastric cancer cells to aggravate the progression of gastric cancer
T cell infiltration. Kaplan-Meier analysis showed reduced overall survival in GC patients with high OTUB2 expression. OTUB2 promotes M2 TAMs polarization and immune evasion in GC. Targeting OTUB2 offers a promising strategy to reshape the GC TME and improve the efficacy of immune checkpoint inhibitors.
Authors
- Guanmo Liu
- Zicheng Zheng (ORCID: https://orcid.org/0000-0002-0984-5849)
- Xin Ye (ORCID: https://orcid.org/0000-0003-2277-5328)
- Yixuan He
- Juan Sun
- Yuqin Liu
- Weiming Kang (ORCID: https://orcid.org/0000-0002-6736-4728)
- Jie Li (ORCID: https://orcid.org/0000-0003-0973-8645)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Cell Death and Disease
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1038/s41419-026-08743-9
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00