Sacituzumab Govitecan as an Effective Strategy for Sensitizing Chemoresistant HNSCC Cells to Senolytic Intervention
studies confirmed that SG treatment followed by ABT-263 limited tumor progression and extended survival without notable toxicity. Thus, SG in combination with senolytic treatment may be an effective strategy for suppressing the growth of cisplatin-resistant HNSCC cells.
Authors
- David A. Gewirtz (ORCID: https://orcid.org/0000-0003-0437-4934)
- Hisashi Harada (ORCID: https://orcid.org/0000-0001-5993-1289)
- Jennifer E. Koblinski (ORCID: https://orcid.org/0000-0002-7156-2030)
- Natalie Luffman
- Bin Hu
Institutions
- Virginia Commonwealth University (US)
- Virginia Cancer Institute (US)
- Commonwealth Cancer Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-15
- DOI
- https://doi.org/10.64898/2026.04.13.718209
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00