Beyond 25(OH)D: Carboxylated Osteocalcin and the Undercarboxylated/Carboxylated Osteocalcin Ratio as Superior Biomarkers for Vitamin D Recovery in Offspring Affected by Maternal Deficiency
: In offspring affected by maternal VDD, vitamin D supplementation improves the osteocalcin carboxylation profile primarily by driving carboxylated osteocalcin synthesis rather than reducing the undercarboxylated pool. Serum cOC and the ucOC/cOC ratio serve as superior functional biomarkers to ucOC for monitoring therapeutic efficacy in this early-life developmental model.
Authors
- Jen‐Shiu Chiang Chiau (ORCID: https://orcid.org/0000-0002-3680-5703)
- Chuen‐Bin Jiang (ORCID: https://orcid.org/0000-0003-2763-3476)
- Shu-Chao Weng (ORCID: https://orcid.org/0000-0001-9242-4502)
- C. Y. Yeung (ORCID: https://orcid.org/0000-0001-7392-9441)
- H C Lee
- Wai‐Tao Chan (ORCID: https://orcid.org/0000-0001-9740-800X)
- Mei-Lein Cheng
- Szu-Wen Chang
Institutions
- Mackay Memorial Hospital (TW)
- Mackay Medical University (TW)
- Mackay Junior College of Medicine, Nursing and Management (TW)
Publication Details
- Journal
- Nutrients
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/nu18081243
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mackay Memorial Hospital