Evaluation of antimycobacterial, antibacterial, and anticancer activities of new nodulisporacid derivatives isolated from endophytic fungus <i>Hypoxylon pulicicidum</i> using <i>in silico</i> studies
had better binding energies with the AGNt protein, which also were greater than those of ciprofloxacin. To the best of our knowledge this is the first report presenting the antimycobacterial properties of each diasteroisomeric form of nodulisporacid derivative, proving that it is a potential antitubercular agent for further development in the pharmaceutical industry.
Authors
- Baruch Ateba Amana (ORCID: https://orcid.org/0000-0003-2549-0520)
- Lasse van Geelen (ORCID: https://orcid.org/0000-0003-3879-4136)
- Tengu Awazi
- Sergi Hervé Akoné
- Viktor E. Simons (ORCID: https://orcid.org/0000-0003-3267-0706)
- Rainer Kalscheuer (ORCID: https://orcid.org/0000-0002-3378-2067)
- Eitel Ngoh Misse Mouelle (ORCID: https://orcid.org/0009-0006-7020-1563)
- Achille Nouga Bissoué (ORCID: https://orcid.org/0000-0001-9235-5965)
- Samuel Magloire Bissim
- Pierre Roger Koliye
- Jean Pierre Longue Ekon
- Y Wang
- Luc Léonard Mbaze Meva’a
Institutions
- Chinese Academy of Tropical Agricultural Sciences (CN)
- University of Douala (CM)
- University of Bamenda (CM)
- Helmholtz Institute for Pharmaceutical Research Saarland (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1080/14786419.2026.2654624
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00