Ionizing radiation enhances CAR T-cell infiltration and efficacy in solid tumors
and demonstrate that irradiating tumors prior to systemic CAR T-cell infusion can increase CAR T-cell infiltration and efficacy in solid tumors.
Authors
- Che-Min Lee (ORCID: https://orcid.org/0000-0003-3294-7760)
- Rocky Shi
- Laura Evgin (ORCID: https://orcid.org/0000-0002-0913-5038)
- Kevin L. Bennewith (ORCID: https://orcid.org/0000-0002-4066-6507)
- Pauline Loos (ORCID: https://orcid.org/0000-0002-0019-5579)
- James M. Piret (ORCID: https://orcid.org/0000-0001-7934-9675)
- Lisa Zhan
- Meredith A. Clark
- Laura E. R. Paulus
- Prabhreet K. Sekhon
Institutions
- University of British Columbia (CA)
- Translational Research in Oncology (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3389/fimmu.2026.1704419
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00