Lineage-specific CK2α deletion reshapes the transcriptome of hematopoietic stem cells toward an immune-primed state
, and AP-1 family members as regulatory hubs driving these inflammatory transcriptional states in CK2α-deficient HSCs. Cell-cell communication profiling revealed multiple gains and losses in ligand-receptor communication between the HSCs and their immune microenvironment in KO. Our findings identify CK2α as a regulator of immune transcriptional programs in HSCs and suggest that disruption of CK2 signaling influences stem cell behavior and immune activation in contexts relevant to hematologic malignancies and CK2-targeted cancer therapies.
Authors
- Katherine Mercer
- Rajesh Rajaiah
- Sinisa Dovat (ORCID: https://orcid.org/0000-0003-3906-6165)
- Yasin Uzun (ORCID: https://orcid.org/0000-0003-3478-3499)
- Chandrika Gowda Behura
- Anush Karampuri
- Hannah Valensi
- Daniyal Muhammad
- Marudhu Shanmugam
- Upendar Golla
Institutions
- Pennsylvania State University (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-15
- DOI
- https://doi.org/10.64898/2026.04.10.717787
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Rally Foundation
- University of Pennsylvania
- Pennsylvania State University
- Four Diamonds
- Penn State College of Medicine
- National Center for Advancing Translational Sciences
- Hyundai Hope On Wheels