Structure-guided screening of FAR-1 antagonists with multi-stage anthelmintic activity
of 56,473 ng/mL at 10 min and a half-life of ~7 h. These data provide evidence that FAR-1 is a promising target for developing anthelmintic drugs.
Authors
- Yaoyu Feng (ORCID: https://orcid.org/0000-0002-8380-1246)
- Y K Li
- Ziding Zhang (ORCID: https://orcid.org/0000-0002-9296-571X)
- Dongjuan Yuan (ORCID: https://orcid.org/0000-0002-5992-3016)
- Fei Shen (ORCID: https://orcid.org/0000-0003-4035-2169)
- Wenmin Qi
- Lihua Xiao (ORCID: https://orcid.org/0000-0001-8532-2727)
- Jinwei Lv
- Juan Wen
- Yu Lin
Institutions
- China Animal Disease Control Center (CN)
- National Center for Emerging and Zoonotic Infectious Diseases (US)
- China Agricultural University (CN)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1128/aac.01226-25
- Primary Topic
- Mollusks and Parasites Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center)
- Basic and Applied Basic Research Foundation of Guangdong Province