Light pollution impairs ovarian function via m6A-dependent miR-421-5p processing-mediated clock disruption
overexpression exacerbated miR-421-5p-mediated CLOCK suppression and cellular dysfunction. Light pollution upregulates METTL14, enhancing m6A-dependent maturation of miR-421-5p, which post-transcriptionally represses CLOCK. This novel epi-transcriptomic mechanism disrupts steroidogenesis and ovulation, offering new insights for preventing pollution-related reproductive diseases.
Authors
- Tingting Zhou (ORCID: https://orcid.org/0000-0002-9967-0068)
- Yuhan Zhang (ORCID: https://orcid.org/0000-0003-1674-1658)
- Yong Tan
- Guicheng Xia
- Jie Chen
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chronobiology International
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1080/07420528.2026.2655702
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China