Glucose-6-phosphate dehydrogenase deficiency and the risk of developing systemic lupus erythematosus

Objective: To explore the relationship between glucose-6-phosphate dehydrogenase (G6PD) deficiency and the risk of developing systemic lupus erythematosus (SLE). Methods: A case-control study was conducted including 516 female SLE patients (SLE group) and 491 age-matched healthy females (control group) from August 2023 to August 2024. G6PD enzymatic activity was detected via the G6PD/6PGD ratio method, and G6PD gene mutations were identified by PCR combined with flow hybridization; 21 G6PD-deficient samples underwent whole-exome sequencing (WES) for genotype verification. The two groups were stratified by enzymatic status, and differences in enzymatic ratios, gene mutation rates and mutation types were compared using rank-sum test and Pearson's chi-square test with SPSS 25.0. Results: > 0.05). Conclusion: G6PD deficiency does not correlate with the risk of developing systemic lupus erythematosus. Funding project: Yangjiang High-level Key Medical and Health Research Project (2023001).