Benzyl-Spacer-Engineered Prodrug: Enabling NIR Fluorescent Activation for Cancer Therapy in a Zebrafish Gallbladder Model
as a robust platform for precise bioimaging and targeted therapy. This work highlights the additional potential of a benzyl spacer in theranostics, wherein the cleavable linker helps enable this NIR-responsive modality for biomedical research.
Authors
- Junhyuk Kim (ORCID: https://orcid.org/0000-0001-9662-9265)
- Michio Iwaoka (ORCID: https://orcid.org/0000-0002-6271-0185)
- David George Churchill (ORCID: https://orcid.org/0000-0002-2520-4638)
- Prasad M. Sonawane
- Arkaprava Roychaudhury (ORCID: https://orcid.org/0000-0003-1497-4909)
- Satish Balasaheb Nimse (ORCID: https://orcid.org/0000-0002-5137-0584)
- Neha Jain (ORCID: https://orcid.org/0000-0001-8144-8162)
- Cheol-Hee Kim
Institutions
- Tokai University (JP)
- Korea Advanced Institute of Science and Technology (KR)
- Chungnam National University (KR)
- Kootenay Association for Science & Technology (CA)
- Malaysia Genome Institute (MY)
- Bioengineering Center (RU)
- Convergence (US)
- Hallym University Medical Center (KR)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00043
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00