DESIGN DEVELOPMENT AND EVALUATION OF MICROSPHERES CONTAINING GLIPIZIDE DRUG

Microspheres can be employed to deliver medication in a rate-controlled and sometimes targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. The purpose of this research was to formulate and system-antically evaluate in vitro performances of microspheres containing glipizide. The % yield of the microspheres significantly increased (p < 0.05) with increasing amount of carriers, which may be due to large amount of the polymers available to form a completely drug loaded microspheres. In terms of % yield, it can be concluded that microspheres prepared with chitosan and eudragit RS100 showed highest values as compared to microspheres prepared with carragenan and eudragit RLPO. Good uniformity in drug encapsulation was found among different batches of the formulations but it had been seen that capabilities of encapsulation efficiency of MCH and MRS were greater as compared to the MCR and MRL formulations. The encapsulation efficiency of the microspheres significantly increased (p < 0.05) with increasing amount of eudragit polymer. From the release data it was revealed that the entire tablet formulations were released above 90% of glipizide within 12 hrs. The release profile of TFMRS2 portrait that the faster release of glipizide was happened as compared to other formulations.