Species-specific effects of positive end-expiratory pressure on diaphragm and chest wall geometry in mice, rats, and humans
Positive end-expiratory pressure, a parameter used to control end-expiratory lung volume in mechanical ventilation, has a smaller effect on diaphragm surface area in mice compared with rats. Compared with healthy volunteers, rats have a larger relative decrease in diaphragm surface area due to more caudal displacement, whereas mice have a similar decrease in diaphragm surface area, but have more widening of the thorax. Interspecies differences have to be taken into account in future (animal) research on the effects of mechanical ventilation on the diaphragm or interaction between lungs, chest wall, and diaphragm.
Authors
- Wout J. Claassen (ORCID: https://orcid.org/0000-0001-5154-7311)
- L M A Heunks
- J. Tim Marcus (ORCID: https://orcid.org/0000-0001-9948-6407)
- Annemijn H. Jonkman (ORCID: https://orcid.org/0000-0001-8778-5135)
- Gustav J. Strijkers (ORCID: https://orcid.org/0000-0001-6700-5058)
- Bram F. Coolen (ORCID: https://orcid.org/0000-0003-3946-653X)
- C Ottenheijm
- Myrte Wennen (ORCID: https://orcid.org/0000-0002-7749-936X)
- Diana Jansen
Institutions
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1152/ajpregu.00258.2025
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw
- National Heart, Lung, and Blood Institute