Prime editing: a new frontier in precision genome engineering for rice improvement
) gene editing, engineered resistance to bacterial blight and herbicide, enhanced heat resilience, and restoration of nutritional traits. Finally, we discuss current challenges related to editing efficiency, delivery, scalability, biosafety, and genetic stability, while outlining future prospects for advanced PE-derived platforms such as twin prime editing (twinPE) and PASTE. Collectively, these advances position PE as a transformative genome editing platform for creating climate-resilient, high-yield, and nutritionally enhanced rice varieties capable of meeting future food security challenges.
Authors
- Bao Tran (ORCID: https://orcid.org/0000-0002-0261-4458)
- Sohaila Abdelhady
- Jelli Venkatesh (ORCID: https://orcid.org/0000-0002-8896-0385)
- Medhat Rehan (ORCID: https://orcid.org/0000-0003-2702-3862)
- Abdulrahman Hatawsh (ORCID: https://orcid.org/0009-0003-3613-7818)
- Soad Auf
- Farida Elkordy
- Nabil Al-Saadi
- Mohamed Abdelrahman
- Ashraqat M. Abdelhamid
- Arwa Sharkawi
Institutions
- Qassim University (SA)
- International Atomic Energy Agency (IT)
- Field Crops Research Institute (VN)
- Agricultural Genetics Institute (VN)
- Nile University (EG)
Publication Details
- Journal
- Frontiers in Plant Science
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3389/fpls.2026.1804263
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qassim University