In Silico Perturbation Identifies Transcription Factors as Protective Targets in HSPCs After Irradiation
, a factor with pharmacological activation potential, was selected for validation via in vivo celastrol treatment and in vitro knockdown. Collectively, our findings uncover the transcriptional programs governing HSPC lineage biases after radiation exposure and highlight the utility of in silico TF perturbation as a strategy for guiding the therapeutic interventions for radiation-induced hematopoietic injury.
Authors
- Shaoting Lv
- Qixiang Liu
- Gangqiao Zhou (ORCID: https://orcid.org/0000-0002-4895-5063)
- H Chen
- Zongjian Tao
- Hao Lu (ORCID: https://orcid.org/0000-0002-0400-5752)
- Yuxing Wang (ORCID: https://orcid.org/0000-0003-3079-5572)
- Caihui Li
- Yiming Lu
- Hongyue Tian
- Qi Zhang
- Qilin Huang
- Yingying Chen
- Cheng Quan
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Academy of Military Medical Sciences (CN)
- Hebei University (CN)
- Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/ijms27083522
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China