Small Molecule Regulation of CLOCK:BMAL1 DNA Binding Activity
CLOCK: . Together, these data demonstrate that small molecules can regulate DNA binding by the circadian transcription factor CLOCK:BMAL1 through occupancy of a PAS domain cavity.
Authors
- Diksha Sharma (ORCID: https://orcid.org/0000-0001-5519-6109)
- McClain Kressman (ORCID: https://orcid.org/0000-0002-1679-8606)
- Carrie L. Partch (ORCID: https://orcid.org/0000-0002-4677-2861)
- Soumendu Boral
- Kevin H. Gardner (ORCID: https://orcid.org/0000-0002-8671-2556)
- Denize C. Favaro (ORCID: https://orcid.org/0000-0001-5563-2548)
- Irene Franco (ORCID: https://orcid.org/0009-0002-8860-3940)
- Ethen West
Institutions
- The Graduate Center, CUNY (US)
- City College of New York (US)
- Howard Hughes Medical Institute (US)
- FMC (United States) (US)
- University of California, Santa Cruz (US)
- University of California San Diego (US)
- CUNY Advanced Science Research Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-14
- DOI
- https://doi.org/10.64898/2026.04.13.718289
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- California Institute for Regenerative Medicine
- University of California, Santa Cruz
- National Institutes of Health