Structure-Guided Identification of Phytochemical OCT2 Inhibitors and Their Functional Relevance to Cisplatin-Induced Cytotoxicity
: This study establishes a structure-guided framework linking phytochemical OCT2 inhibition to nephroprotective potential and identifies methoxylation as a major determinant of OCT2-targeted intervention strategies.
Authors
- Hui Li
- Yoon‐Jee Chae (ORCID: https://orcid.org/0000-0003-4921-4192)
- K C Lee
- Hyerim Song
- Mi-Kyung Lee
Institutions
- Konyang University (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Woosuk University (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/pharmaceutics18040486
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Ministry of Food and Drug Safety
- Korea Research Institute of Chemical Technology
- Ministry of Education, India