Association of biofilm formation with multidrug resistance in burn wound patients isolates of Pseudomonas aeruginosa in Sana’a City, Yemen

Background: is recognized for its ability to acquire multidrug resistance (MDR) and form biofilms that enhance virulence and antimicrobial tolerance. Objective: isolates from burn wound infections in Sana'a City, Yemen. Methods: ≤ 0.05 considered significant. Results: > 0.05). Conclusion: remains the leading cause of burn wound infections in Sana'a City, Yemen, exhibiting alarmingly high levels of carbapenem and cephalosporin resistance. Although biofilm formation was common, no significant association was found between biofilm production and multidrug resistance. The high prevalence of PDR strains underscores the urgent need for antimicrobial stewardship, routine susceptibility testing, and infection control measures in burn centers.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-04-15
DOI
https://doi.org/10.3389/fmed.2026.1762684
Primary Topic
Bacterial biofilms and quorum sensing
Type
article
Field-Weighted Citation Impact
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article

Association of biofilm formation with multidrug resistance in burn wound patients isolates of Pseudomonas aeruginosa in Sana’a City, Yemen

Abdulrahman Y. Al-Haifi, Yaser Mohammed Al‐Worafi, Ali Salman Al-Shami, Hammood Mohammed Naji Saad et al.
Frontiers in Medicine
Bacterial biofilms and quorum sensing
article

Association of biofilm formation with multidrug resistance in burn wound patients isolates of Pseudomonas aeruginosa in Sana’a City, Yemen

Abdulrahman Y. Al-Haifi, Yaser Mohammed Al‐Worafi, Ali Salman Al-Shami, Hammood Mohammed Naji Saad, Ahmed Yahia Al-Jaufy, Ansam M. Al-Barq, Hude Z. Al-Shami, Abdulhakim M. Al-Saban, Zaid Abdo Thawaba, Abdullah Ahmed Al-Dhabali, Eshtiaq A. Al-Yosffi, Abdullah H. Maad, Ahlam Ali Maher
article en

Abstract

Background: is recognized for its ability to acquire multidrug resistance (MDR) and form biofilms that enhance virulence and antimicrobial tolerance. Objective: isolates from burn wound infections in Sana'a City, Yemen. Methods: ≤ 0.05 considered significant. Results: > 0.05). Conclusion: remains the leading cause of burn wound infections in Sana'a City, Yemen, exhibiting alarmingly high levels of carbapenem and cephalosporin resistance. Although biofilm formation was common, no significant association was found between biofilm production and multidrug resistance. The high prevalence of PDR strains underscores the urgent need for antimicrobial stewardship, routine susceptibility testing, and infection control measures in burn centers.

Frontiers in MedicineVol. 13
Sana'a University (YE), Alta View Hospital (US), College of Medical Sciences (NP), Thamar University (YE), Al-Saeeda University (YE), Al-Ameen College of Pharmacy (IN), Oklahoma State University Center for Health Sciences (US), Lebanese International University (LB)
Good health and well-being
Openalex Percentile: Top 25%
Bacterial biofilms and quorum sensing
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