Subunit vaccination using Atomic Layering Thermostable Antigen and Adjuvant (ALTA®) platform elicits enhanced humoral and cellular immune responses
-formulated protein and polysaccharide antigens elicited strong humoral and cell-mediated immunity, suggesting potential broad applicability of the platform to vaccines against various diseases, including cancer and infections from intracellular pathogens.
Authors
- Sineenart Sengyee (ORCID: https://orcid.org/0000-0001-8560-699X)
- Keith A. Strand (ORCID: https://orcid.org/0000-0001-8885-0162)
- Lorena R. Antúnez (ORCID: https://orcid.org/0000-0002-8030-309X)
- Sky W. Brubaker (ORCID: https://orcid.org/0000-0003-1488-6079)
- Federico Urbano-Muñoz
- Emma M. Snyder
- Matthew Lewis (ORCID: https://orcid.org/0000-0001-7973-0716)
- Mary N. Burtnick (ORCID: https://orcid.org/0000-0001-6763-4348)
- Isabella R. Walters
- Sarah B Weiby
- Annie B. Caplan
- Paul J. Brett
- Daria L. Ivanova
Institutions
- University of Nevada, Reno (US)
- Mahidol University (TH)
- Applied DNA Sciences (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3389/fimmu.2026.1787216
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Defense Threat Reduction Agency