Exploring pain-motor dynamics: preliminary insights through exploration of descending inhibition and corticospinal excitability

Introduction: Previous studies have linked endogenous pain modulation and corticospinal excitability (CSE), but methodological limitations and overlooking psychological factors may have constrained interpretations. This study aimed to evaluate the interaction between CSE excitability in different muscles and endogenous pain modulation, and to determine whether kinesiophobia and pain catastrophizing modulate this interaction. Methods: and the maximum response parameters of input-output curves (plateau) for the anterior deltoid (AD) and first dorsal interosseous (FDI) muscles, first in pain-free then in painful condition induced by the application of capsaicin cream to the shoulder. Results: shift) and CPM response, shedding new light on the influence of psychological factors on pain-induced CSE alterations and their link with descending pain inhibition. Discussion: These findings underscore the complex interplay between corticospinal projections, pain modulation, and psychological factors, reinforcing the need for further investigation.