Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo

reduction in bacterial loads on implanted devices and surrounding tissues, comparable with high-dose rifampicin, and significantly reduced local inflammation. These findings position CorA as a promising candidate for preventing and managing staphylococcal biofilm-associated infections, warranting further investigation into its clinical potential.

Authors

Institutions

Publication Details

Journal
ChemMedChem
Published
2026-04-14
DOI
https://doi.org/10.1002/cmdc.202501057
Primary Topic
Bacterial biofilms and quorum sensing
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo

Sabryna Junker, Stefania De Benedetti, Andrea Schiefer, Hedda Schrey et al.
ChemMedChem
Bacterial biofilms and quorum sensing
article

Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo

Sabryna Junker, Stefania De Benedetti, Andrea Schiefer, Hedda Schrey, Tanja Schneider, Markus Bischoff, Isabel Bodenstein, Katharina Rox, Ahmad Aljohmani, Syeda J. Khalid, Noran Abdel Wadood, Carolin Ade, Miriam Große, Mathias Müsken, Sören L. Becker, Daniela Yildiz, Achim Hoerauf, Gabriela Krasteva‐Christ, Kenneth Pfarr, Haoxuan Zeng, N. Kirilov, Maximilian Förster
article en

Abstract

reduction in bacterial loads on implanted devices and surrounding tissues, comparable with high-dose rifampicin, and significantly reduced local inflammation. These findings position CorA as a promising candidate for preventing and managing staphylococcal biofilm-associated infections, warranting further investigation into its clinical potential.

ChemMedChemVol. 21(7)
University Hospital Bonn (DE), German Center for Infection Research (DE), Helmholtz Centre for Infection Research (DE), Institute of Medical Microbiology and Hygiene (DE), Helmholtz Institute for Pharmaceutical Research Saarland (DE), Saarland University (DE), Technische Universität Braunschweig (DE)
Deutsches Zentrum für Infektionsforschung
Life below water
Openalex Percentile: Top 21%
Bacterial biofilms and quorum sensing
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.