Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo
reduction in bacterial loads on implanted devices and surrounding tissues, comparable with high-dose rifampicin, and significantly reduced local inflammation. These findings position CorA as a promising candidate for preventing and managing staphylococcal biofilm-associated infections, warranting further investigation into its clinical potential.
Authors
- Sabryna Junker (ORCID: https://orcid.org/0000-0001-9846-4505)
- Stefania De Benedetti (ORCID: https://orcid.org/0000-0001-9284-9623)
- Andrea Schiefer (ORCID: https://orcid.org/0000-0002-9823-2090)
- Hedda Schrey (ORCID: https://orcid.org/0000-0003-0079-8908)
- Tanja Schneider (ORCID: https://orcid.org/0000-0001-7269-4716)
- Markus Bischoff (ORCID: https://orcid.org/0000-0001-6734-2732)
- Isabel Bodenstein
- Katharina Rox (ORCID: https://orcid.org/0000-0002-8020-1384)
- Ahmad Aljohmani (ORCID: https://orcid.org/0000-0003-0982-3583)
- Syeda J. Khalid (ORCID: https://orcid.org/0009-0001-7549-9622)
- Noran Abdel Wadood (ORCID: https://orcid.org/0000-0001-6108-1797)
- Carolin Ade
- Miriam Große (ORCID: https://orcid.org/0000-0001-5972-639X)
- Mathias Müsken (ORCID: https://orcid.org/0000-0002-5624-1378)
- Sören L. Becker (ORCID: https://orcid.org/0000-0003-3634-8802)
- Daniela Yildiz (ORCID: https://orcid.org/0000-0002-9702-8581)
- Achim Hoerauf (ORCID: https://orcid.org/0000-0002-8671-3831)
- Gabriela Krasteva‐Christ (ORCID: https://orcid.org/0000-0002-0113-521X)
- Kenneth Pfarr (ORCID: https://orcid.org/0000-0003-3096-2465)
- Haoxuan Zeng
- N. Kirilov
- Maximilian Förster
Institutions
- University Hospital Bonn (DE)
- German Center for Infection Research (DE)
- Helmholtz Centre for Infection Research (DE)
- Institute of Medical Microbiology and Hygiene (DE)
- Helmholtz Institute for Pharmaceutical Research Saarland (DE)
- Saarland University (DE)
- Technische Universität Braunschweig (DE)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1002/cmdc.202501057
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Infektionsforschung