Identification of novel protein biomarkers correlating with both cardiac and skeletal muscle indices in duchenne muscular dystrophy
-values. The median age was 15.0 years (12.7-17.9 interquartile range). Of 1128 proteins analyzed, 208 correlated with only cardiac indices; 14 correlated with only skeletal muscle indices; 10 proteins correlated strongly with both indices. Protein functions included (1) calcium regulation, (2) cardiac remodeling, (3) cell homeostasis, (4) fibrosis, (5) inflammation, (6) lipid regulation, and (7) other.ConclusionOur nontargeted proteomics study identified serum biomarkers correlating with skeletal and cardiac progression in DMD. Candidate proteins-some uniquely associated with skeletal or cardiac indices and others overlapping-offer promising leads for studies to improve risk stratification and guide targeted therapies in DMD.
Authors
- Christopher F. Spurney (ORCID: https://orcid.org/0000-0003-2493-5735)
- W. Bryan Burnette (ORCID: https://orcid.org/0000-0002-7637-5330)
- Katheryn Gambetta (ORCID: https://orcid.org/0000-0002-1796-9171)
- Jaclyn G. Tamaroff (ORCID: https://orcid.org/0000-0002-3630-9937)
- Jonathan H. Soslow (ORCID: https://orcid.org/0000-0001-9194-5330)
- Meng Xu (ORCID: https://orcid.org/0000-0001-7387-0734)
- Mark Naguib (ORCID: https://orcid.org/0009-0009-7403-7731)
- Rachel Harris (ORCID: https://orcid.org/0009-0008-4287-3658)
- Larry Markham
- for the DMDCCC
- Christopher Slaughter
Institutions
- Northwestern University (US)
- Indiana University Health (US)
- Lurie Children's Hospital (US)
- Children's National (US)
- Vanderbilt University (US)
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Neuromuscular Diseases
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1177/22143602261438533
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Food and Drug Administration
- National Heart, Lung, and Blood Institute
- National Center for Research Resources
- National Center for Advancing Translational Sciences