Electrospun Multilayer Scaffolds Based on Poly (L-Lactic Acid) and Poly (Acrylonitrile) Reinforced with CaO Nanoparticles for Enhanced Skin Regeneration and Wound Healing
showed that CaO significantly reduced bacterial viability, with PLA/PAN/CaO achieving the highest inhibition (up to 37.1%). In vitro HaCaT assays and in vivo implantation in BALB/c mice confirmed high cytocompatibility and biocompatibility. These findings demonstrate that multilayer electrospinning of PLA/PAN/CaO enables the design of structurally integrated, bioactive, and mechanically balanced scaffolds for advanced wound healing and dermal repair.
Authors
- Fabián Guajardo
- Diana Ginette Zárate-Triviño (ORCID: https://orcid.org/0000-0002-0852-8948)
- Lissette Montoille
- Paula A. Zapata (ORCID: https://orcid.org/0000-0003-3361-6226)
- Mauricio Gómez (ORCID: https://orcid.org/0000-0003-2010-5910)
- Daniel Canales (ORCID: https://orcid.org/0000-0002-2691-6864)
- Claudio García‐Herrera (ORCID: https://orcid.org/0000-0002-1283-8551)
- Eugenio Rivera (ORCID: https://orcid.org/0000-0001-8103-2706)
- Carlos Loyo (ORCID: https://orcid.org/0000-0003-4177-2958)
- Fabián Álvarez-Carrasco (ORCID: https://orcid.org/0009-0000-2506-4623)
- Esmeralda Lopez Toro (ORCID: https://orcid.org/0000-0001-5540-7199)
- Juan José Martinez
- Sebastián Romero
Institutions
- Universidad de Santiago de Chile (CL)
- Universidad Autónoma de Nuevo León (MX)
- Adolfo Ibáñez University (CL)
- Universidad Yachay Tech (EC)
- Universidad Bernardo O'Higgins (CL)
- University of the Americas (CL)
- Center for Engineering and Industrial Development (MX)
Publication Details
- Journal
- Polymers
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/polym18080960
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Santiago de Chile
- Agencia Nacional de Investigación y Desarrollo