Insulin Resistance and Ad-Hoc Hypotheses

Type 2 diabetes is explained in the conventional model as a state of insulin resistancewith receptor defects, signaling pathway defects, and inflammation. This article argues thatinsulin resistance is not a signaling defect but a logistical problem: the glycogen storesare full. Insulin is a post-it note, glucose is distilled sunlight, and glycans are the body’slanguage. When one cuts away, the need for ad-hoc hypotheses disappears. Falsification issimple: fasting followed by a ketogenic diet normalizes all parameters. Type 2 diabetes isonly a chronic disease if one makes it so.