Rapid and Dense Immobilization of Nucleic Acids on Lanthanide-Doped Nanoparticles for Enhanced-Sensitivity Förster Resonance Energy Transfer-Based Diagnostics
MXene nanosheets. This platform achieved an ultralow limit of detection of 8.5 pM for SARS-CoV-2 oligonucleotides, representing a 107.5-fold improvement. Importantly, the biosensor was successfully validated using real COVID-19 clinical samples, effectively distinguishing between negative and positive results. The presented DNA functionalization strategy holds immense potential for advancing the design and synthesis of diverse nucleic acid-functionalized nanomaterials for advanced therapeutic and diagnostic applications.
Authors
- Bo Wei (ORCID: https://orcid.org/0000-0001-7386-2689)
- Xinyue Lao
- Man‐Chung Wong (ORCID: https://orcid.org/0000-0001-5453-8576)
- J W Liu
- L LI
- Menglin Song (ORCID: https://orcid.org/0000-0001-6091-0485)
- Jianhua Hao
- Baoyu Zhang
Institutions
- Hong Kong Polytechnic University (HK)
- University of Waterloo (CA)
- Sun Yat-sen University (CN)
- South China Normal University (CN)
- National Institute for Nanotechnology (CA)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Laser Research Institute (CN)
Publication Details
- Journal
- ACS Sensors
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acssensors.5c04782
- Primary Topic
- MXene and MAX Phase Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sun Yat-sen University
- Research Grants Council, University Grants Committee
- Hong Kong Polytechnic University
- Guangzhou Municipal Science and Technology Project