Repeated semaglutide treatment attenuates cocaine-vs-food choice in male and female rats
The present study determined the effectiveness of the glucagon-like peptide 1 agonist semaglutide to attenuate cocaine-vs-food choice in male and female rats. Repeated 5-day semaglutide treatment decreased cocaine choice and significantly reduced body weight. These preclinical results support the clinical evaluation of semaglutide as a candidate cocaine use disorder medication.
Authors
- Samuel A. Marsh (ORCID: https://orcid.org/0009-0000-9753-5586)
- Matthew L. Banks (ORCID: https://orcid.org/0000-0003-4949-5246)
- Nicholas Heslep
Institutions
- Virginia Commonwealth University (US)
Publication Details
- Journal
- Neuropsychopharmacology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1038/s41386-026-02386-2
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Drug Abuse