Multi-omics landscape of lung mycobiome dysbiosis: Candida albicans drives the invasive progression of lung adenocarcinoma

as the pivotal biomarker distinguishing invasive from indolent lesions. Crucially, functional integration reveals that this fungal enrichment is not merely an association but appears to actively orchestrate a pro-tumorigenic shift in the host's immune and metabolic landscape. These findings uncover a novel fungal-driven mechanism of tumor invasiveness, suggesting that the lung mycobiome serves as both a hidden driver of progression and a valuable target for early therapeutic intervention.