Canonical WNT Ligands Produced by Regulatory T Cells Restrain Effector CD4 <sup>+</sup> T Cell Responses
T cell responses. This work reveals a previously underappreciated pathway through which Tregs regulate immune activity and identifies WNT signaling as a potential target for modulating inflammatory immune responses.
Authors
- Igal Ifergan
- Kashish Singh Parihar
- Margaret R. Niemeier (ORCID: https://orcid.org/0009-0008-6413-2869)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-14
- DOI
- https://doi.org/10.64898/2026.04.12.717050
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cincinnati Children's Hospital Medical Center
- National Institutes of Health