Gene-Breastfeeding Interaction on Body Mass Index Among Chinese Twins Aged 2−18 Years

: 0.57, 95% CI [0.44, 0.72]) in the 12- to 14-year age group. Additionally, breastfeeding significantly modified the additive genetic component of BMI in the 6- to 8-year age group and 12- to 14-year age group. In the 6- to 8-year age group, breastfeeding decreased the impact of genes on BMI, with a genetic effect modification coefficient (βa) of -0.19 (-0.25, -0.13). In the 12- to 14-year age group, breastfeeding increased the impact of genes on BMI, with a genetic effect modification coefficient (βa) of 0.08 (0.02, 0.15). In conclusion, as age increases, the genetic influence on children's BMI becomes more pronounced. Breastfeeding may modulate genetic effects at the ages of 6-8 and 12-14. Given the metabolic diversity of obesity, our findings offer insight into how breastfeeding interacts with genetic background, helping to unravel the complex gene-environment interplay influencing obesity.

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Publication Details

Journal
Twin Research and Human Genetics
Published
2026-04-15
DOI
https://doi.org/10.1017/thg.2026.10052
Primary Topic
Nutrition, Genetics, and Disease
Type
article
Field-Weighted Citation Impact
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article

Gene-Breastfeeding Interaction on Body Mass Index Among Chinese Twins Aged 2−18 Years

Min Yu, Yilin Pang, S C Wang, D. Wang et al.
Twin Research and Human Genetics
Nutrition, Genetics, and Disease
article

Gene-Breastfeeding Interaction on Body Mass Index Among Chinese Twins Aged 2−18 Years

Min Yu, Yilin Pang, S C Wang, D. Wang, Wenjing Gao, Zhong Dong, Chunxiao Liao, X P Wu, F Wu, Hui Cao, C Q Yu, Weihua Cao, Tao Huang, Jun Lv, Jinyi Zhou, Jie Yin, Shengli Yin, Dianjianyi Sun, Liming Li
article en

Abstract

: 0.57, 95% CI [0.44, 0.72]) in the 12- to 14-year age group. Additionally, breastfeeding significantly modified the additive genetic component of BMI in the 6- to 8-year age group and 12- to 14-year age group. In the 6- to 8-year age group, breastfeeding decreased the impact of genes on BMI, with a genetic effect modification coefficient (βa) of -0.19 (-0.25, -0.13). In the 12- to 14-year age group, breastfeeding increased the impact of genes on BMI, with a genetic effect modification coefficient (βa) of 0.08 (0.02, 0.15). In conclusion, as age increases, the genetic influence on children's BMI becomes more pronounced. Breastfeeding may modulate genetic effects at the ages of 6-8 and 12-14. Given the metabolic diversity of obesity, our findings offer insight into how breastfeeding interacts with genetic background, helping to unravel the complex gene-environment interplay influencing obesity.

Twin Research and Human Genetics
King University (US), Shanghai Medical College of Fudan University (CN), Peking University (CN), Ministry of Education (RO), Tianjin Centers for Disease Control and Prevention (CN), Jiangsu Provincial Center for Disease Control and Prevention (CN), Yunnan Center for Disease Control And Prevention (CN), Zhejiang Center for Disease Control and Prevention (CN), Taiwan Centers for Disease Control (TW), Beijing Center for Disease Prevention and Control (CN), Sichuan Center for Disease Control and Prevention (CN)
Good health and well-being
Openalex Percentile: Top 15%
Nutrition, Genetics, and Disease
DOISourceOpenAlex
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