Picolinamides with β-Thiophosphorylated Amine Residues as a Useful Scaffold to Generate Biologically Active Pd(II) Pincer Complexes
-complexes were studied for in vitro cytotoxicity against several solid and hematopoietic cancer cell lines, as well apoptosis induction and DNA damage ability, which showed their promising anticancer properties. In addition, moderate antibacterial activity was observed for a representative palladocycle of the β-thiophosphorylated derivatives.
Authors
- Nikolay Kalitin
- Ya. V. Ryzhmanova (ORCID: https://orcid.org/0000-0003-2987-5604)
- Ekaterina Yu. Rybalkina (ORCID: https://orcid.org/0000-0002-3068-0233)
- Yulia L. Volodina (ORCID: https://orcid.org/0000-0003-4388-3344)
- Zinaida S. Klemenkova
- Оleg I. Аrtyushin (ORCID: https://orcid.org/0000-0001-6333-5973)
- V. A. Kozlov
- Aleksandra A. Kalashnikova
- Yulia V. Nelyubina
- Diana V. Aleksanyan
- Anna Yu. Katranova
Institutions
- D. Mendeleyev University of Chemical Technology of Russia (RU)
- ITMO University (RU)
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
- Ministry of Health of the Russian Federation (RU)
- G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms (RU)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/ijms27083525
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation
- Ministry of Science and Higher Education of the Russian Federation
- Ministry of Health of the Russian Federation