Real-world effect of vitrectomy combined with intravitreal conbercept for treatment of vitreous haemorrhage in proliferative diabetic retinopathy (QILIN I): a prospective cohort study

AIMS: To evaluate the efficacy of intravitreal conbercept (IVC) combined with pars-plana vitrectomy (PPV) for severe, non-clearing vitreous haemorrhage (VH) caused by proliferative diabetic retinopathy (PDR) in real-world practice. METHODS: This prospective, observational, multicentre, cohort study enrolled 523 patients with VH due to PDR at 26 hospitals from August 2022 to June 2024. Patients were treated with preoperative IVC (3-7 days prior to PPV), intraoperative IVC (at completion of PPV) and PPV alone as control. The primary outcome was the incidence of early (7-30 days) postoperative VH (POVH). Secondary outcomes included late POVH (30-180 days), postoperative best-corrected visual acuity (BCVA) and distribution of POVH severity. RESULTS: Of 425 participants (425 eyes) finally enrolled, 406 completed 30-day-visit, and 341 completed 180-day-visit. The incidence of early POVH was 24.0% (36 of 150) in preoperative IVC versus 23.2% (33 of 142) intraoperative IVC compared with 37.6% (50 of 133) in control (p=0.0160, 0.0122). The incidence of late POVH was 11.9% (16 of 134) in preoperative IVC versus 17.5% (20 of 114) intraoperative IVC versus 17.8% (19 of 107) in control (p=0.4109, 0.4661). The early POVH was less severe in preoperative and intraoperative IVC cohorts compared with control (p=0.0067, 0.0304), while the severity of late POVH was comparable (p=0.4860, 0.8353). Mean postoperative BCVA was all improved but showed no significant intergroup differences (p>0.05). CONCLUSIONS: This study, with the largest participants to date, demonstrates that IVC administered preoperatively or intraoperatively effectively reduces early POVH incidence, rather than late POVH. Preoperative IVC may be preferable for patients with more severe baseline disease characteristics.

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Journal
British Journal of Ophthalmology
Published
2026-04-15
DOI
https://doi.org/10.1136/bjo-2025-329066
Primary Topic
Retinal Diseases and Treatments
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article
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article

Real-world effect of vitrectomy combined with intravitreal conbercept for treatment of vitreous haemorrhage in proliferative diabetic retinopathy (QILIN I): a prospective cohort study

Mingxin Ao, X Li, Qinghua Qiu, Qing Chang et al.
British Journal of Ophthalmology
Retinal Diseases and Treatments
article

Real-world effect of vitrectomy combined with intravitreal conbercept for treatment of vitreous haemorrhage in proliferative diabetic retinopathy (QILIN I): a prospective cohort study

Mingxin Ao, X Li, Qinghua Qiu, Qing Chang, Yuhua Hao, Hua Yan, Jinglin Huang, Chunchao Bi, X M, Quanhong Han, Junjie Ye, Xuemin Jin, Hui Peng, J S Li, Zhizhong Ma, Ronghan Wu, Yanming Huang, Mengyu Liao, Fan Zhang, Jianhong Liang, Bo Li, Zhijun Wang, Yi Lei, Han Han, Xiaobing Yu, Dawei Sun, Guohong Zhou, Suyan Li, Hai Lu, Yuanyuan Liu, Jie Zhong, Yuntao Hu
article en

Abstract

AIMS: To evaluate the efficacy of intravitreal conbercept (IVC) combined with pars-plana vitrectomy (PPV) for severe, non-clearing vitreous haemorrhage (VH) caused by proliferative diabetic retinopathy (PDR) in real-world practice. METHODS: This prospective, observational, multicentre, cohort study enrolled 523 patients with VH due to PDR at 26 hospitals from August 2022 to June 2024. Patients were treated with preoperative IVC (3-7 days prior to PPV), intraoperative IVC (at completion of PPV) and PPV alone as control. The primary outcome was the incidence of early (7-30 days) postoperative VH (POVH). Secondary outcomes included late POVH (30-180 days), postoperative best-corrected visual acuity (BCVA) and distribution of POVH severity. RESULTS: Of 425 participants (425 eyes) finally enrolled, 406 completed 30-day-visit, and 341 completed 180-day-visit. The incidence of early POVH was 24.0% (36 of 150) in preoperative IVC versus 23.2% (33 of 142) intraoperative IVC compared with 37.6% (50 of 133) in control (p=0.0160, 0.0122). The incidence of late POVH was 11.9% (16 of 134) in preoperative IVC versus 17.5% (20 of 114) intraoperative IVC versus 17.8% (19 of 107) in control (p=0.4109, 0.4661). The early POVH was less severe in preoperative and intraoperative IVC cohorts compared with control (p=0.0067, 0.0304), while the severity of late POVH was comparable (p=0.4860, 0.8353). Mean postoperative BCVA was all improved but showed no significant intergroup differences (p>0.05). CONCLUSIONS: This study, with the largest participants to date, demonstrates that IVC administered preoperatively or intraoperatively effectively reduces early POVH incidence, rather than late POVH. Preoperative IVC may be preferable for patients with more severe baseline disease characteristics.

British Journal of Ophthalmology
Ningbo University (CN), Hebei Medical University (CN), Beijing Tongren Hospital (CN), Harbin Medical University (CN), Xuzhou Medical College (CN), Shanghai Jiao Tong University (CN), Xiamen University (CN), Dalian Medical University (CN), Peking University (CN), Wenzhou Medical University (CN), China-Japan Friendship Hospital (CN), Peking Union Medical College Hospital (CN), Tianjin Medical University General Hospital (CN), Affiliated Eye Hospital of Wenzhou Medical College (CN), Shaanxi Provincial People's Hospital (CN), Fourth Affiliated Hospital of China Medical University (CN), Second Affiliated Hospital of Dalian Medical University (CN), Fourth Hospital of Hebei Medical University (CN), Tongren Hospital (CN), Eye & ENT Hospital of Fudan University (CN), Beijing Hospital (CN), Peking University People's Hospital (CN), Peking University First Hospital (CN), Shanxi Eye Hospital (CN), Second Affiliated Hospital of Harbin Medical University (CN), First Affiliated Hospital of Dalian Medical University (CN), Peking University Third Hospital (CN), Xuzhou No.1 People's Hospital (CN), Tianjin Medical University Eye Hospital (CN), Beijing Tsinghua Chang Gung Hospital (CN), First Affiliated Hospital of Zhengzhou University (CN), Qilu Hospital of Shandong University (CN), First Hospital of Xi'an (CN), Tianjin Medical University (CN), Chongqing Medical University (CN), China Medical University (CN)
National Natural Science Foundation of China, China Postdoctoral Science Foundation, Natural Science Foundation of Tianjin City
Good health and well-being
Openalex Percentile: Top 11%
Retinal Diseases and Treatments
DOISourceOpenAlex
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