Increasing MeCP2 protein in Pitt-Hopkins syndrome model (Tcf4) mice does not affect abnormal myelination but induces the generation of astrocytes
mice in the presence of the MECP2 transgene, as well as the presence of cells with astrocytic morphology in the brains of these animals, suggesting a potential interplay of MeCP2 and TCF4 in astrocyte development.
Authors
- Yuta Moxley
- Sheryl Anne D. Vermudez (ORCID: https://orcid.org/0000-0002-7020-8347)
- Geanne A. Freitas
- Hemangi Rajpal
- Colleen M. Niswender (ORCID: https://orcid.org/0000-0001-6009-8212)
- Rocco G. Gogliotti (ORCID: https://orcid.org/0000-0003-0254-7643)
- Aditi Buch
Institutions
- Loyola University Chicago (US)
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Molecular and Cellular Neuroscience
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1016/j.mcn.2026.104094
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pitt Hopkins Research Foundation
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke