Clinical features and outcomes of herpes simplex viral infections with co-infection in 100 children

Objective: To analyze the clinical features, laboratory findings, and treatment outcomes of febrile hospitalized children with herpes simplex virus (HSV) detected by serological and/or molecular biological tests, and to provide an evidence-based basis for the early clinical screening, differential diagnosis and targeted intervention of HSV in pediatric febrile cases. Methods: < 0.05 was considered statistically significant. Results: < 0.001). Conclusion: HSV is a frequently isolated pathogen in febrile infants and young children with herpetic gingivostomatitis as the core clinical diagnosis and diverse clinical manifestations dominated by non-specific systemic and oropharyngeal symptoms (cutaneous herpes with low incidence). HSV infection is often accompanied by co-detection of other pathogens such as EBV and Bordetella pertussis (diagnosed by standardized serological, PCR and microbial culture methods) and abnormal liver function in some cases. Early HSV-PCR detection combined with serological testing, timely and individualized acyclovir treatment (with clear course standards) based on comprehensive clinical judgment can significantly improve the clinical outcomes of febrile children with HSV detected. Comprehensive intervention targeting co-detected pathogens and complications is equally important for the clinical management of such cases.