The zinc–nitric oxide axis in acute brain injury: Convergent oxidative–nitrative stress, peroxynitrite signaling, and therapeutic targets
axis is a central driver of redox-dependent injury, and highlight therapeutic strategies targeting this network, including zinc modulation, NO pathway regulation, peroxynitrite scavenging, and mitochondrial protection. In conclusion, targeting the Zn-NO axis as a unified redox hub may limit secondary injury propagation and improve neuroprotection in acute brain injury.
Authors
- Hyun Ho Jeong (ORCID: https://orcid.org/0000-0002-2491-3694)
- Hyun Wook Yang (ORCID: https://orcid.org/0009-0004-8070-4063)
- Sang Won Suh (ORCID: https://orcid.org/0000-0002-7492-579X)
- Min Jae Park
Institutions
- Hallym University (KR)
Publication Details
- Journal
- Redox Biology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1016/j.redox.2026.104173
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea