Embryonic Lead Acetate Exposure Induces Seizure-like Activity in Zebrafish Larvae
: Our findings suggest that embryonic lead exposure leads to morphological defects and seizure susceptibility, demonstrating lead's neurotoxic potential during early development. Seizure-like behaviors occurred in a non-linear concentration-dependent manner with a photosensitive component, and elevated baseline neural excitability was confirmed by local field potential (LFP) recordings.
Authors
- James A. Marrs (ORCID: https://orcid.org/0000-0003-3449-7126)
- Priyadharshini Manikandan (ORCID: https://orcid.org/0000-0001-7965-2308)
- Theodore Cummins (ORCID: https://orcid.org/0000-0001-9509-6380)
- Angela Gyamfi
- William Cisneros
- Christopher A. Subi-Kasozi (ORCID: https://orcid.org/0009-0007-0757-7186)
Institutions
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/biomedicines14040897
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- MIT Media Lab
- Common Fund