Genome-wide CRISPR screens in primary human natural killer cells identify countermeasures against immunosuppressive environment
stress. These findings establish a scalable platform for CRISPR-based functional genomics in primary NK cells and reveal engineering targets to enhance NK cell persistence and efficacy in tumor microenvironments.
Authors
- Hsin-An Shih (ORCID: https://orcid.org/0000-0001-8613-0700)
- Steven Lin (ORCID: https://orcid.org/0000-0002-7542-4663)
- Jason Cheng-Yu Chang
- Ching-Wen Cheng
- Jenifer Faustine
- Shu-Yu Ho
- Tsu-Lan Chao
- Yi-Jun Lan
- Cheng-Chieh Chen
Institutions
- National Taiwan University (TW)
- Institute of Biological Chemistry, Academia Sinica (TW)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1038/s41467-026-71895-x
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00