Modified Sampson-NIH LDL-C Equation

The Modified Sampson–NIH LDL-C equation is a tool for estimating low-density lipoprotein cholesterol (LDL-C). Designed to improve upon the original Sampson equation, this updated model demonstrates improved accuracy, particularly at lower LDL-C thresholds (55 mg/dL and 70 mg/dL). The equation was developed with β-quantification, the gold standard for LDL-C measurement. While it is an extension of the well-known Sampson-NIH LDL-C equation, because it involves an update to the model, further validation should be considered and these limitations recognized before using.