Empirical antibiotic therapy in acute orthopaedic infections: differences in antimicrobial susceptibility across anatomical sites

Cefazolin monotherapy is insufficient as an empirical treatment for early postoperative orthopaedic infections at our centre. Vancomycin-ceftriaxone offers high coverage for most anatomical sites and aligns with SWAB recommendations. For foot and ankle infections, vancomycin-ciprofloxacin offers superior coverage.