ESGO Consensus Statement on endometrial cancer prevention, risk reduction strategies, and management of women with Lynch syndrome
Lynch syndrome (LS) is a hereditary condition associated with an increased susceptibility to developing cancer, primarily colorectal and gynaecological cancer (endometrial cancer and ovarian cancer). The European Society of Gynaecological Oncology (ESGO) nominated fifteen practicing multidisciplinary clinicians with expertise in this field and ten gynaecological and oncological fellows with interest in the topics to develop evidence-based statements, sharing and standardizing the management of LS carriers. Published evidence was integrated with clinical experience to reach Consensus Statements through anonymous voting. In this Consensus, thirty-one statements based on the best available evidence and expert agreement are offered. They focused on genetic and cancer risk counseling principles, screening procedures, risk-reducing surgical and medical strategies, and address emerging topics such as reproductive issues for LS carriers, which are important in current practice. This manuscript reports the Statements that reached a consensus, their voting results, and a summary of supporting evidence.
Authors
- Vesna Kesić (ORCID: https://orcid.org/0000-0002-3513-7192)
- Simona Duranti (ORCID: https://orcid.org/0000-0002-1924-238X)
- Bilal Esat Temiz (ORCID: https://orcid.org/0000-0002-4329-1376)
- Sarah Bowden (ORCID: https://orcid.org/0000-0003-1843-7342)
- Frédéric Amant (ORCID: https://orcid.org/0000-0002-5452-4905)
- Toni T. Seppälä (ORCID: https://orcid.org/0000-0002-4940-3498)
- Ranjit Manchanda (ORCID: https://orcid.org/0000-0003-3381-5057)
- Beyhan Ataseven (ORCID: https://orcid.org/0000-0002-2823-7590)
- Hasan Volkan Ege (ORCID: https://orcid.org/0000-0002-4056-9037)
- Murat Gültekin (ORCID: https://orcid.org/0000-0002-4221-4459)
- Veronika Seebacher-Shariat
- Carolina Maria Sassu (ORCID: https://orcid.org/0000-0002-1702-5859)
- Nicolò Bizzarri (ORCID: https://orcid.org/0000-0002-1727-904X)
- Vasilis Theodoulidis (ORCID: https://orcid.org/0000-0002-7924-5224)
- Maria Kyrgiou (ORCID: https://orcid.org/0000-0002-7165-0735)
- Cláudia Marchetti (ORCID: https://orcid.org/0000-0001-7098-8956)
- François Planchamp (ORCID: https://orcid.org/0000-0002-8709-0410)
- Nina Pauly
- Hélène Didelot
- Mev Dominguez-Valentin
- Giovanni Scambia
- Maurizio Genuardi
- LecuruFabrice Lécuru
- Laura Burney Ellis
- Stephan Polterauer
- Mihaela Grigore
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of London (GB)
- Oslo University Hospital (NO)
- Imperial College Healthcare NHS Trust (GB)
- Queen Mary University of London (GB)
- Aristotle University of Thessaloniki (GR)
- Barts Health NHS Trust (GB)
- Telio (Norway) (NO)
- Agostino Gemelli University Polyclinic (IT)
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- University of Belgrade (RS)
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL)
- Tampere University Hospital (FI)
- Klinikum Lippe (DE)
- Klinikum Bielefeld (DE)
- Tampere University (FI)
- Institut Bergonié (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Imperial College London (GB)
- Hacettepe University (TR)
- Medical University of Vienna (AT)
- Institut Curie (FR)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1016/j.ejca.2026.116739
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00