Demonstration of Gliadin Penetration into the Epidermis by Tape Stripping as Prerequisite for Percutaneous Sensitisation in Wheat Allergy
= 0.27). No correlation was observed between EIS-assessed skin barrier status and gliadin penetration. Serum gliadin was not increased after epicutaneous wheat application. This study using TS demonstrates for the first time that wheat allergens penetrated into the epidermis but could not be detected in the serum. Neither wheat allergy nor skin barrier status was associated with increased stratum corneum penetration. These findings suggest that epidermal uptake alone may not be sufficient to explain sensitisation.
Authors
- K Brockow
- T Biedermann
- Katharina Anne Scherf (ORCID: https://orcid.org/0000-0001-8315-5400)
- Valentina Faihs (ORCID: https://orcid.org/0000-0002-6019-2521)
- Tomoharu Yokooji (ORCID: https://orcid.org/0000-0002-2535-6295)
- Claudia Kugler
- Hiroaki Matsuo (ORCID: https://orcid.org/0000-0002-8730-5389)
- Charlotte Jasmin Kiani
- Barbara Maier
- Ida Folda
Institutions
- Hiroshima University (JP)
- Odense University Hospital (DK)
- Hiroshima University Hospital (JP)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/ijms27083536
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft