Astro-Versus Microglia-Enriched Transcriptomes from Aged Atxn2-CAG100-Knockin Mice Suggest Underlying Pathology of RNA Processing at Ribosomes, and Possibly at U-Bodies
appeared increased in astroglial and microglial fractions. These transcriptome data suggest altered ribosomal and spliceosome machinery, with massive microgliosis versus mild astrogliosis, at the core of SCA2 and ALS13.
Authors
- Suzana Gispert
- Jana Key (ORCID: https://orcid.org/0009-0002-3208-1805)
- Arvind Reddy Kandi (ORCID: https://orcid.org/0000-0002-4020-1769)
- Rajkumar Vutukuri (ORCID: https://orcid.org/0000-0002-7890-9471)
- Nesli-Ece Şen
- Georg Auburger (ORCID: https://orcid.org/0000-0001-7355-2701)
- Luis E. Almaguer-Mederos (ORCID: https://orcid.org/0000-0003-0887-2359)
Institutions
- Goethe University Frankfurt (DE)
- University Hospital Frankfurt (DE)
Publication Details
- Journal
- Cells
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/cells15080699
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft