Specific Aneuploidies Predict Immune Evasion and Poor Immunotherapy Response in Melanoma
T-cell infiltration, B-cell infiltration, tumor mutational burden, and PD-L1 status. These findings establish chromosome 1q gain as a compelling biomarker of immunotherapy resistance in melanoma and highlight aneuploidies as underappreciated drivers of immune evasion in this disease.
Authors
- Shini Chen (ORCID: https://orcid.org/0009-0008-1441-1739)
Institutions
- Institut Pasteur (FR)
- Group Image (Poland) (PL)
- Caris Life Sciences (United States) (US)
- New York University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-15
- DOI
- https://doi.org/10.64898/2026.04.12.718039
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Foundation for Cancer Research
- Melanoma Research Alliance
- Pershing Square Sohn Cancer Research Alliance
- National Institutes of Health