A Sustainable and Potentially Cost-Effective Approach to the Antimalarial Drug KAF156 (Ganaplacide)
-Boc-protected drug. The final step leads to an easily isolated and high yielding HCl salt of KAF156, this route outperforming the previously reported approach in terms of sustainability, reaction and workup time, and yield.
Authors
- R.M. Lammert (ORCID: https://orcid.org/0000-0002-7675-0583)
- Karthik S. Iyer (ORCID: https://orcid.org/0000-0003-4566-2721)
- Bruce H. Lipshutz (ORCID: https://orcid.org/0000-0001-9116-7049)
- Jordan R. Yirak (ORCID: https://orcid.org/0009-0008-7649-842X)
Institutions
- University of California System (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.joc.6c00422
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Division of Chemistry