The orphan receptor GPR84 drives inflammation in Buruli ulcer development
expression through Toll-like receptor 2 engagement, promoting proinflammatory cytokine release through a self-amplifying loop that sustained receptor expression and inflammatory signaling. Moreover, pharmacological inhibition of GPR84 with the antagonist PBI-4050, in combination with antibiotics, accelerated tissue repair in infected GPR84-competent mice, which was associated with attenuation of inflammatory responses. Together, these findings establish GPR84 as a promising target for host-directed therapeutic interventions in Buruli ulcer and its expression as a potential biomarker of lesion activity.
Authors
- Line Ganlonon
- Florian Tarnaud
- Étienne Meunier (ORCID: https://orcid.org/0000-0002-3651-4877)
- João Fevereiro (ORCID: https://orcid.org/0000-0003-1566-9930)
- Nathalie Labarrière (ORCID: https://orcid.org/0000-0002-1407-6546)
- Laurent Marsollier (ORCID: https://orcid.org/0000-0001-5497-5995)
- Ambroise Adeye
- Pascale Pignon
- Marie Robbe-Saule (ORCID: https://orcid.org/0000-0001-7358-8173)
- Jorge Pedrosa (ORCID: https://orcid.org/0000-0002-8204-4888)
- Vincent Dubée (ORCID: https://orcid.org/0000-0002-9982-4741)
- Nicolas Gouault (ORCID: https://orcid.org/0000-0002-5527-8566)
- Alexandra G. Fraga (ORCID: https://orcid.org/0000-0003-2029-1629)
- Guillaume Lebon (ORCID: https://orcid.org/0000-0003-1162-5148)
- Aurélie Sauvager (ORCID: https://orcid.org/0000-0002-2838-9623)
- Priscille Brodin (ORCID: https://orcid.org/0000-0003-0991-7344)
- Marianne Lafont (ORCID: https://orcid.org/0000-0002-1810-5850)
- Mélanie Foulon (ORCID: https://orcid.org/0000-0002-6988-1112)
- Estelle Marion (ORCID: https://orcid.org/0000-0003-4917-9665)
- Edouard Yeramian
- Ivo Gomperts Boneca
- Laurence Touami
- Ludovic Martin
- Anne Croué
Institutions
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pasteur (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Université Paris Cité (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Université Rennes 2 (FR)
- Institut des Sciences Chimiques de Rennes (FR)
- Ministère de la Santé (TN)
- Center for Infection and Immunity of Lille (FR)
- Toulouse Mathematics Institute (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Institut de Génomique Fonctionnelle (FR)
- Nutrition, métabolismes et cancer (FR)
- Université d'Angers (FR)
- Université de Rennes (FR)
- Nantes Université (FR)
- University of Minho (PT)
Publication Details
- Journal
- Science Translational Medicine
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1126/scitranslmed.ads8681
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondation pour la Recherche Médicale
- Société Française de Dermatologie et de Pathologie Sexuellement Transmissible
- Universite Angers
- Conseil Régional des Pays de la Loire
- Fondation Raoul Follereau