Artemisia scoparia extract inhibits oxidative stress and ferroptosis to ameliorate MASH through AGE-RAGE and JAK1-STAT3 signaling

Background: in the context of MASH remain poorly understood. Aim of the study: extract (AS) on a MASH mice model. Methods: , with the therapeutic efficacy of AS being characterized through the detection of biochemical markers, histological analysis, and Oil red O staining. To elucidate the underlying mechanisms and pharmacodynamic basis of AS, a comprehensive set of techniques were applied, including transcriptomics, metabolomics, Western blotting, and immunofluorescence staining. Results: . Conclusion: This study first elucidates the mechanism through which AS ameliorates MASH through integrated multi-omics analysis, providing experimental evidence for further development of natural therapeutic agents.