Limited Effectiveness of <scp>IL</scp> ‐17 Inhibitors for Anti‐ <scp>TNF</scp> ‐Induced Psoriasis in Hidradenitis Suppurativa: A Multicenter Retrospective Study
BACKGROUND: Paradoxical psoriasis (PP) is a known adverse event of anti-tumor necrosis factor (anti-TNF) agents in hidradenitis suppurativa (HS), yet evidence regarding its management remains limited. The objective was to assess the effectiveness of interleukin-17 inhibitors (IL-17i) in treating anti-TNF-induced PP in patients with HS. METHODS: This multicenter retrospective study included 40 adults with HS who developed PP during anti-TNF therapy and were subsequently treated with IL-17i. Outcomes for PP were measured using the Physician's Global Assessment (PGA); HS severity was evaluated using the International Hidradenitis Suppurativa Severity Score System (IHS4) and Hurley scores. Paired comparisons were performed using the Wilcoxon signed-rank or McNemar's test, as appropriate. Multivariate analysis was performed using LASSO-regularized logistic regression. Missing data were managed by multiple imputation. RESULTS: Of the patients, 27.5% achieved a clinically meaningful PP response, while 45% experienced worsening. Female sex, older age at HS onset, and prior exposure to secukinumab were associated with nonresponse. Conversely, HS severity improved significantly in 70% of patients (p < 0.001). CONCLUSIONS: IL-17i showed limited effectiveness for anti-TNF-induced PP in HS, though improvement in hidradenitis was observed.
Authors
- Júlia Verdaguer‐Faja (ORCID: https://orcid.org/0000-0002-9482-1621)
- Juan José Lluch‐Galcerá (ORCID: https://orcid.org/0000-0002-8373-4303)
- Pablo Fernández‐Crehuet (ORCID: https://orcid.org/0000-0001-7837-7332)
- Júlia Mercader-Salvans (ORCID: https://orcid.org/0000-0001-8662-3003)
- Vania Lukoviek Araya
- Antonio Guilabert Vidal
- Patricia Garbayo‐Salmons (ORCID: https://orcid.org/0000-0003-3325-6785)
- Laura Parra‐Navarro
- Verónica Mora‐Fernández (ORCID: https://orcid.org/0000-0003-0016-9781)
- Jorge Romaní (ORCID: https://orcid.org/0000-0002-6134-5155)
- Sofía Haselgruber (ORCID: https://orcid.org/0000-0002-8432-0954)
- Alejandro Molina‐Leyva (ORCID: https://orcid.org/0000-0001-6882-2113)
- Miguel Sampayo-Cordero (ORCID: https://orcid.org/0000-0003-1469-3410)
- Albert Martin‐Poch (ORCID: https://orcid.org/0009-0003-9002-1779)
- Gemma Martin-Ezquerra
- José Manuel Carrascosa
- Leonardo Bascón (ORCID: https://orcid.org/0000-0001-9621-8538)
- Maria Sin‐Soler
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universidad de Granada (ES)
- Hospital Universitario de Canarias (ES)
- Universitat Internacional de Catalunya (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Hospital General de Granollers (ES)
- Corporació Sanitària Parc Taulí (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Hospital Universitario Reina Sofía (ES)
- Parc de Salut (ES)
- Hospital Universitari Sagrat Cor (ES)
- Hospital Universitari de Vic (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
Publication Details
- Journal
- International Journal of Dermatology
- Published
- 2026-04-14
- DOI
- https://doi.org/10.1111/ijd.70420
- Primary Topic
- Hidradenitis Suppurativa and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00