Characterization of a pancreatic cancer GWAS signal suggests PDX1 buffers stress in the exocrine pancreas
expression, eroding PDX1's capacity to buffer stress and stabilize epithelial cell fate in the exocrine compartment.
Authors
- Irene Collins (ORCID: https://orcid.org/0000-0001-5434-4659)
- Efsun Arda
- Daina Eiser
- Katelyn E. Connelly (ORCID: https://orcid.org/0000-0002-1693-5519)
- Laufey T. Ámundadóttir (ORCID: https://orcid.org/0000-0003-1859-8971)
- Gauri Prasad (ORCID: https://orcid.org/0000-0003-2698-4952)
- Jun Zhong
- Jason W. Hoskins (ORCID: https://orcid.org/0000-0001-6944-1996)
- Trevor A. Christensen
- Erin Char (ORCID: https://orcid.org/0009-0003-1700-0867)
- Aidan O’Brien (ORCID: https://orcid.org/0000-0003-2188-4223)
- Minal Patel
- Michael Mobaraki
Institutions
- National Institutes of Health (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-15
- DOI
- https://doi.org/10.64898/2026.04.13.26350790
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Government of Ontario
- National Institutes of Health
- National Cancer Institute