Structural Basis for BD1-Preferring 2,4-Disubstituted Pyrimidine BRDT Inhibitors
are among the best BRDT-BD1-preferring inhibitors reported to date and demonstrate a significant step toward identifying highly selective BRDT inhibitors for male contraception.
Authors
- Xianghong Guan (ORCID: https://orcid.org/0000-0002-7874-8065)
- Prakriti Kalra (ORCID: https://orcid.org/0000-0002-0840-3176)
- Taimeng Liang
- William C. K. Pomerantz (ORCID: https://orcid.org/0000-0002-0163-4078)
- Logan H. Sigua (ORCID: https://orcid.org/0000-0002-1469-5398)
- Gunda I. Georg (ORCID: https://orcid.org/0000-0002-8900-9460)
- Jon E. Hawkinson (ORCID: https://orcid.org/0000-0001-5461-7071)
- Jonathan Solberg
- Jun Qi (ORCID: https://orcid.org/0000-0002-1461-3356)
- Ernst Schönbrunn
- Alice Chan
- Rui Shi
Institutions
- University of Minnesota (US)
- Moffitt Cancer Center (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00180
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medicinal Chemistry Division, American Chemical Society
- National Institute of General Medical Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development