Cardiac disease prediction using extended network with positron emission tomography (PET) images

Objective: This study aims to improve Left Ventricle (LV) quantification accuracy and efficiency in cardiac disease diagnosis using automated image analysis. Methods: We propose XNet, a deep learning framework based on an extended convolutional network with multi-task learning. XNet segments LV structures estimates Regional Wall Thickness (RWT) and classifies cardiac phases (systole/diastole) from 2D Positron Emission Tomography (PET) sequences. The model integrates spatial and temporal features and is trained on augmented PET datasets. Results: XNet outperformed existing methods, achieving a mean absolute error of 1.5 mm, classification accuracy of 98.5%, validation accuracy of 97.2%, and a loss of 0.048. It showed strong performance in low-contrast and varied-quality image conditions, reducing myocardial area estimation error by 38.6% compared to baseline models. Conclusion: XNet provides a robust, accurate, and fully automated solution for LV quantification, offering a reliable tool to support clinical diagnosis and treatment planning in cardiovascular care.